De Brinvilliers poisoned her father, brother, and two sisters in order to inherit their property, with the help of her lover, army captain Godin de Sainte-Croix. There were also rumours that she had poisoned poor people during her visits to hospitals.
She fled but was arrested in Liège.
The trial of the Marquise de Brinvilliers led to the Poison affair.
 Fictional portrayals
Her case was portrayed fictionally by Arthur Conan Doyle in "The Leather Funnel", by Alexandre Dumas, père in "The Marquise de Brinvilliers", and by Émile Gaboriau in "Intrigues of a Poisoner". Robert Browning's 1846 poem "The Laboratory" imagines an incident in the life of Marie Madeleine Marguerite d'Aubray Brinvilliers. Her capture & burning is mentioned in The Oracle Glass by Judith Merkle Riley. In the novel The Burning Court by John Dickson Carr, the plot concerns a murder that seems to have been committed by the ghost of Marie d'Aubray Brinvilliers.